Affinity-Based Detection of Ligand-Encoded Synthetic Biomarkers

The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are described. These nanoparticles can be used to detect in vivo enzyme activity. The invention also relates to products, kits, and databases for use in the methods of the invention.

Researchers

David Wood / Gabriel Kwong / Kevin Lin / Andrew Warren / Sangeeta Bhatia

Departments: Health Sciences and Technology Program
Technology Areas: Biotechnology: Sensors & Monitoring / Diagnostics: Assays
Impact Areas: Healthy Living

  • affinity-based detection of ligand-encoded synthetic biomarkers
    United States of America | Granted | 10,527,619
  • affinity-based detection of ligand-encoded synthetic biomarkers
    China | Published application
  • affinity-based detection of ligand-encoded synthetic biomarkers
    Japan | Granted | 6,847,660
  • affinity-based detection of ligand-encoded synthetic biomarkers
    European Patent Convention | Granted | 3,004,374
  • affinity-based detection of ligand-encoded synthetic biomarkers
    Japan | Granted | 7,017,544
  • affinity-based detection of ligand-encoded synthetic biomarkers
    United States of America | Granted | 11,977,074
  • affinity-based detection of ligand-encoded synthetic biomarkers
    United Kingdom | Granted | 3,004,374
  • affinity-based detection of ligand-encoded synthetic biomarkers
    Japan | Granted | 7,368,868
  • affinity-based detection of ligand-encoded synthetic biomarkers
    Japan | Pending
  • affinity-based detection of ligand-encoded synthetic biomarkers
    China | Published application

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