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Thermal Imaging-based State Estimation of a Stefan Problem with Application to Cell Thawing

Technology / Case number: #24616
Allan S. Myerson / Richard D Braatz / Qihang Zhang / Moo Sun Hong / Ajinkya Pandit / Prakitr Srisuma / George Barbastathis
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Label-Free Detection of Oligonucleotide Hybridization Using Anchored Single-Walled Carbon Nanotube Corona Phase

Technology / Case number: #24626
Michael S. Strano / Xun Gong / Sooyeon Cho / Xiaojia Jin / Sungyun Yang / Jianqiao Leslie Cui
Technology Areas: Chemicals & Materials / Diagnostics / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Dielectric Films for the Control of Cell Adhesion

Technology / Case number: #23881
Victor Leon / Baptiste Blanc / Sophia Sonnert / Kripa K Varanasi
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Advanced Materials
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Novel Chimeric Antigen Receptor Signaling Domains Derived via Activity-based Directed Evolution

Technology / Case number: #21116
Michael Birnbaum / Taeyoon Kyung
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Optimization of Circular Single Stranded DNA using M13 Phage

Technology / Case number: #21211
Christopher Voigt / Uyanga Tsedev / Tae-Gon Cha / Angela Belcher
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Characterization and Utilization of a Subgenomic Promoter Mutant Library for Tuning Expression of Multiple Transgenes from Alphavirus Replicons

Technology / Case number: #21309
Ron Weiss / Jin Huh
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Endogenous Gene Sensing and Actuation by Placement of Non-Coding RNA after Transcriptional Termination Signals

Technology / Case number: #21520
James Collins / Ron Weiss / Jeremy Gam / Elvira Vitu / Casper Enghuus
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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A Fabrication-Free Microfluidic Device for Scalable, High-Volume Bacterial Electroporation

Technology / Case number: #23552
Cullen R. Buie / Po-Hsun Huang / Sijie Chen
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Activity-based Cell Sorting

Technology / Case number: #23765HJ
Jesse Kirkpatrick / Ava Soleimany / Sangeeta Bhatia
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Library-Scale Methods for Antibody Functional Screening

Technology / Case number: #24645
Brandon DeKosky
Technology Areas: Biotechnology / Diagnostics / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Mammalian Synthetic Biology Approaches for the Precise Control of mAb N-Glycosylation (Pfizer-MIT PTM Track 2 Interim Joint Summary Document)

Technology / Case number: #19972J
Timothy K Lu / Ron Weiss / Nevin Summers / Wen Tseng / Leonid Gaidukov / Michelle Chang / Giyoung Jung / Richard Cornell / Jeffrey Marshall / John Scarcelli / Bruno Figueroa
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Systems and Assays for Identifying PU.1 Inhibitors

Technology / Case number: #21734P
Li-Huei Tsai / William Ralvenius / Alison Mungenast
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald T Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Anti-Human KLRB1 Monoclonal Antibodies and Uses Thereof

Technology / Case number: #21645J
Kai Wucherpfennig / Byong Ha Kang / Nathan Mathewson / Karl Dane Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Split Intein-based Selection for Modified Peptide Binders to SARS-CoV-2 Spike Protein

Technology / Case number: #22502
Christopher Voigt / Emerson Glassey / Andrew King
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Multicellular Integrated Brain Tissue for Investigation and Therapeutic Discovery in Neurological Diseases

Technology / Case number: #22618P
Li-Huei Tsai / Joel Blanchard / Robert Langer / Alice Stanton / Adele Bubnys
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Constriction-Minimizing Microfluidic Devices Enabling Co-Culture in Engineered Hydrogels

Technology / Case number: #24723P
Li-Huei Tsai / Robert Langer / Alice Stanton
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Methods for Machine-Learning Guided Protein Design

Technology / Case number: #25084
Omar Abudayyeh / Jonathan S. Gootenberg / Kaiyi Jiang / Matteo Di Bernardo
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Molecular Time Capsules Enable Transcriptomic Recording in Living Cells

Technology / Case number: #25337
Gene-Wei Li / Mirae Parker / Jack Rubien / Dylan McCormick
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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