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Machine-Learning Optimized Proteins and Enzymes

Technology / Case number: #26015J
Omar Abudayyeh / Jonathan S. Gootenberg / Lukas Villiger / Kaiyi Jiang / Matteo Di Bernardo / Zhaoqing Yan
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Diminished Proteolytic Shedding of Receptor Tyrosine Kinases Mediates MEK Inhibitor Resistance in Triple-Negative Breast Cancer

Technology / Case number: #16742
Aaron Meyer / Miles Miller / Madeleine Oudin / Linda Griffith / Douglas Lauffenburger / Frank Gertler
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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  • Women's Health
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A Self-Derived Energy Force in Graphene/Metal-Phthalocyanine Catalyst for Dual CO2

Technology / Case number: #25330
T. Alan Hatton / Maryam Mokhtarifar / Maryam Abdinejad
Technology Areas: Chemicals & Materials / Energy & Distribution / Environmental Engineering
Impact Areas: Connected World
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Extended Transient Transfection by Repeated Delivery of RNA

Technology / Case number: #13415
Matthew Angel / Mehmet Yanik
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Surface Binding of Nanoparticles-Based Drug Delivery to Tissue

Technology / Case number: #15731
Rohit N Karnik / Cliff Wong / Ambika Bajpayee / Alan Grodzinsky / Moungi G Bawendi
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Nanoparticle Technology for Immune Response Against Small and Macromolecules-Method of Preparation and Uses Thereof

Technology / Case number: #13399J
Frank Alexis / Pamela Basto / Ulrich Von Andrian / Elliot Moseman / Matteo Iannacone / Jinjun Shi / Elena Tonti / Robert Langer / Omid Farokhzad
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Glycan-Receptor Binding of the Novel Influenza A Virus H7N9 Hemagglutinin

Technology / Case number: #16359
Akila Jayaraman / Kannan Tharakaraman / Nathan Stebbins / Rahul Raman / Ram Sasisekharan
Technology Areas: Diagnostics / Therapeutics
Impact Areas: Healthy Living
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Engineering Microbes and Metabolic Pathways for the Production of Ethylene Glycol from Xylose, Glucose, Carbohydrates and Renewable Resources

Technology / Case number: #15064
Deepak Dugar / Brian Pereira / Marjan De Mey / Jose Avalos / Gregory Stephanopoulos
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Brd4 as a Prognostic Indicator and Modulator of the Cell Response to DNA Damage

Technology / Case number: #15011
Scott Floyd / Michael Yaffe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Inhibition of Histone Deacetylase 2 Facilitates Extinction of Aversive Memory

Technology / Case number: #13759HBJRQ
Li-Huei Tsai / Stephen Haggarty / Jisong Guan / Edward Holsen / Florence Wagner / Johannes Graff
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Programmable Gene Insertion with Paired Targeting Guides

Technology / Case number: #24104
Omar Abudayyeh / Jonathan S. Gootenberg
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Synergistic Tumor Treatment with Extended-PK IL-2 & Monoclonal Antibodies

Technology / Case number: #15627
Shuning (Annie) Gai / Byron Kwan / Karl Dane Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Vaccine Nanotechnology and Uses Thereof

Technology / Case number: #12788J
Frank Alexis / Liangfang Zhang / Pamela Basto / Ulrich Von Andrian / Tobias Junt / Elliot Moseman / Matteo Iannacone / Robert Langer / Omid Farokhzad
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Universal RNA-Binding Protein Based on the Pumilio Domain Architecture

Technology / Case number: #17629TE
Edward Stuart Boyden / Katarzyna Adamala / Daniel Martin Alarcon
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Biomarkers and Therapeutics for Autism Spectrum Disorders

Technology / Case number: #13589P
Damon Page / Mriganka Sur
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Copper Oxide Surfaces for Enhanced Condensation

Technology / Case number: #15479
Evelyn N. Wang / Ryan Enright / Young Suk Nam / Nenad Miljkovic
Technology Areas: Chemicals & Materials / Environmental Engineering
Impact Areas: Sustainable Future, Advanced Materials
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Generation of Specialized, High-Value Cells and Tissues from Human Induced Pluripotent Stem Cells by Recapitulating Early Embryogenesis Using Gata Factor-Induced Endoderm

Technology, Tangible Property / Case number: #16205
Ron Weiss / Patrick Guye / Mohammad Reza Ebrahimkhani
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Method for High Efficiency in Vivo Gene Editing

Technology / Case number: #17117H
Wen Xue / Joseph Dorkin / Hao Yin / Tyler Jacks / Daniel Anderson
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Programmable Drug Delivery Profiles of Tumor-Targeted Bacteria

Technology / Case number: #15818H
Tal Danino / Sangeeta Bhatia
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Non-Contact Voltage and Current Monitoring

Technology / Case number: #16022
James Paris / John Donnal / Jin (Jinyeong) Moon / Christopher Schantz / Steven Leeb
Technology Areas: Energy & Distribution / Environmental Engineering / Industrial Engineering & Automation
Impact Areas: Climate Stabilization
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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