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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Ron Weiss / Yingzhong Li / Jan Lonzaric / Parisa Yousefpour / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Gamma Entrainment using Sensory Stimuli Alleviate Cognitive Deficits and Neuroinflammation Induced by Chemotherapy Agents

Technology / Case number: #22066P
Li-Huei Tsai / TaeHyun Kim
Technology Areas: Biotechnology / Sensing & Imaging
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Eric Dane / Masanori Okaniwa / Darrell J Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Multiplexed in Vivo Disease Sensing with Nucleic Acid-Barcoded Reporters enabling CRISPR-Cas-based Detection

Technology / Case number: #21723H
Liang Hao / Renee Zhao / Chayanon Ngambenjawong / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Peter DeMuth / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Systems and Assays for Identifying PU.1 Inhibitors

Technology / Case number: #21734P
Li-Huei Tsai / William Ralvenius / Alison Mungenast
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Circular, Strained Zymogen

Technology / Case number: #21110J
Ronald T Raines / Ian Windsor
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Use of Choline Supplementation as Therapy for APOE4-Related Disorders

Technology / Case number: #20957WPJ
Li-Huei Tsai / Yuan-Ta Lin / Julia Bonner / Priyanka Narayan / Greg Sienski
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification

Technology / Case number: #20788J
Jeremiah A. Johnson / Yivan Jiang / Hung Nguyen / Alexandre Detappe / Irene Ghobrial / Michael Agius / Aiden Wang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Gene Therapy in Mammalian Cells by the use of the Strand Displacement Reaction

Technology / Case number: #21486
Ron Weiss / Giulio Alighieri
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Anti-Human KLRB1 Monoclonal Antibodies and Uses Thereof

Technology / Case number: #21645J
Kai Wucherpfennig / Byong Ha Kang / Nathan Mathewson / Karl Dane Wittrup
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Single-Dose Combination Immunotherapy Augments Responses to Checkpoint Blockades for the Treatment of Cancer

Technology / Case number: #21150H
Chensu Wang / Darrell J Irvine / Karl Dane Wittrup
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Immunostimulatory Nanoparticle Adjuvants

Technology / Case number: #20798HJ
Murillo Silva / Yu Kato / Shane Crotty / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Enhanced Endogenous Recombination for Gene Therapy and Genetic Engineering

Technology / Case number: #20008M
Guoping Feng / Jonathan Wilde / Tomomi Aida / Martin Wienisch / Qiangge Zhang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Split Intein-based Selection for Modified Peptide Binders to SARS-CoV-2 Spike Protein

Technology / Case number: #22502
Christopher Voigt / Emerson Glassey / Andrew King
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Peptide-Encoded Libraries of Small Molecules for De Novo Drug Discovery

Technology / Case number: #23712
Bradley L. Pentelute / Nathalie Grob / Simon Roessler / Stephen Buchwald
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Paul Barone / Richard D Braatz / Anthony Sinskey / Stacy Springs / Moo Sun Hong / Vivekananda Bal
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Multicellular Integrated Brain Tissue for Investigation and Therapeutic Discovery in Neurological Diseases

Technology / Case number: #22618P
Li-Huei Tsai / Joel Blanchard / Robert Langer / Alice Stanton / Adele Bubnys
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Replacing Synthetic Fertilizers by Engineering Cereal-Associated Nitrogen-Fixing Bacteria to Release Urea

Technology / Case number: #25157
Christopher Voigt / Phillip Clauer
Technology Areas: Agriculture & Food / Biotechnology
Impact Areas: Sustainable Future
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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