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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Eric Dane / Masanori Okaniwa / Darrell J Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Preferential Crystallization of fullrAAVs in a Hanging Drop Crystallizer as an Alternative Method for Downstream Purification of rAAV-based Gene Therapies

Technology / Case number: #24870
Paul Barone / Richard D Braatz / Anthony Sinskey / Stacy Springs / Moo Sun Hong / Vivekananda Bal
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Medical Recordkeeping Microneedles

Technology / Case number: #24923
Ana Jaklenec / Robert Langer / Maria Kanelli / Jooli Han / Yang Liu / Fredo Durand (he/him/his)
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Carbon Nanoparticles for use as a Vehicle to Target and Treat Macrophages, and Macrophage RNF41 as a Molecule Essential to Switch Macrophage Phenotype

Technology / Case number: #22023
Elazer R Edelman / Pedro Melgar Lesmes
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Catheter for Intracardiac 3D Bioprinting

Technology / Case number: #22338J
Jennifer Lewis / Sebastien Uzel / Ellen Roche / Keegan Mendez / Connor Verheyen / Victor Damptey / Milen Shishkov / Sophie Wang / Markus Horvath / Brett E Bouma
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Fusion Capsid Therapy for COVID-19 and Applies to Other Viruses: Universal "Dominant" Antiviral to Prevent Virus Evolution and Future Pandemics (DNA/RNA/Protein)

Technology, Tangible Property / Case number: #22801MH
Edward Stuart Boyden / Robert Langer / Alexi Choueiri / Yong Qian / Bowen Li / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Organogels for Epidermal Drug Delivery

Technology / Case number: #23303J
Xuanhe Zhao / Xinyue Liu / Xiaoyu Chen / Weibo Wang
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living, Advanced Materials
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Nucleic Acid-Conjugated Polymeric Nanoparticles for Gene Therapy

Technology / Case number: #23628JQ
Natalie Artzi / Pere Dosta Pons / Alexander M Cryer
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Adhesive, Injectable Hydrogels for Local Therapy Delivery to Brain Tumors

Technology / Case number: #24170JQ
Natalie Artzi / Michelle Dion / Dahis Daniel
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Stable and Efficient Cell Surface Coupling of Nanoparticles

Technology / Case number: #17836HQ
Yiran Zheng / Li Tang / Darrell J Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Lipid Nanoparticles for Drug Delivery to Microglia in the Brain

Technology / Case number: #23156P
Li-Huei Tsai / Owen Fenton / Joel Blanchard / Robert Langer / Jason Andresen / Julia Bonner / William Ralvenius
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Interfacial Bioconjugation on Emulsion Droplets

Technology / Case number: #20314
Qifan Zhang / Timothy Manning Swager
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging
Impact Areas: Advanced Materials
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Antibody Mediated Delivery of Antigen to B Cell Follicles for Enhanced Humoral Response

Technology / Case number: #24727H
Aereas Aung / Darrell J Irvine
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Multi-Targeted, Tunable, Sustained Delivery of Drugs and Other Payloads to Charged Avascular Tissues

Technology / Case number: #21303
Yamini Krishnan / Alan Grodzinsky
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Targeting Dendritic Cell Lectins with Glycosylated Particles Containing TLR Ligands Facilitates Efficient Immune Responses

Technology / Case number: #24570J
Laura L Kiessling / Valerie Lensch / M.G. Finn / Mohammad Murshid Alam / Robert Hincapie
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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RNA-Loaded Lipid Nanoparticle (LNP)

Technology, Tangible Property / Case number: #24973H
B.j. Kim / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Persistent Carbene Monolayers on Silicon Substrates

Technology / Case number: #18755
Jeremiah A. Johnson / Aleksandr Zhukhovitskiy
Technology Areas: Chemicals & Materials / Drug Delivery / Sensing & Imaging
Impact Areas: Advanced Materials
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DNA Virus Launched RNA Replicon System (VREP) for Prolonged and High Level Expression of Transgenes with High Precision Controls

Technology / Case number: #20866
Ron Weiss / Jacob Becraft / Jin Huh
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Chiral Oligotriazoles with Precise Structures

Technology / Case number: #19866
Jeremiah A. Johnson / Yivan Jiang / Hung Nguyen / Yoshiki Shibuya
Technology Areas: Chemicals & Materials / Drug Delivery
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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