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Self Actuating Systems for Retention and Electrical Stimulation in the Gastrointestinal Tract

New
Technology / Case number: #20292JQ
Giovanni Traverso / Taylor Bensel / Alex Abramson / Minsoo Khang / Niclas Roxhed / Ester Caffarel Salvador / David Dellal / Robert Langer
Technology Areas: Biomaterials & Bioelectronics / Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Solid Formulations with Ultra-High Drug Loading

New
Technology / Case number: #19446J
Giovanni Traverso / Taylor Bensel / Alex Abramson / Minsoo Khang / Niclas Roxhed / Ester Caffarel Salvador / Robert Langer
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Multi-Pronged Self-Orienting Millimeter-Scale Actuator for Drug Delivery

New
Technology / Case number: #21169JQ
Giovanni Traverso / Alex Abramson / Robert Langer / Michael Williams / Jacob Wainer
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Injectable, Thermogelling, Prolonged-Release Hydrogel Formulations for CPG-ODNs

New
Technology / Case number: #26051J
Giovanni Traverso / Ameya Kirtane / Robert Langer / Avik Som / Jan-Georg Rosenboom / Eric Wehrenberg-Klee / Stephen Linderman
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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A Simple Watermark for Language Model

New
Technology / Case number: #25701
Elchanan Mossel
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML)
Impact Areas: Connected World
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mRNA-based Myeloid Cell Stimulation Enhances Therapeutic Efficacy

New
Technology / Case number: #25731J
Ralph Weissleder / Akash Gupta / Kaelan Reed / Riddha Das / Christopher Garris / Daniel Anderson
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Artificial Intelligence Training Core with Coincidence Counting Unit

New
Technology / Case number: #25350
Jeehwan Kim / Giho Lee
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science
Impact Areas: Connected World
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Bridging Design Gaps: A Parametric Data Completion Approach With Graph-Guided Diffusion Models

New
Technology / Case number: #25903J
Nikos Arechiga / Faez Ahmed / Yanxia Zhang / Rui Zhou / Chenyang Yuan / Frank Permenter / Matt Klenk
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science
Impact Areas: Connected World
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Self-Righting Systems, Methods, and Related Components

New
Technology / Case number: #20706JQ
Giovanni Traverso / Taylor Bensel / Alex Abramson / Minsoo Khang / Niclas Roxhed / Ester Caffarel Salvador / Robert Langer
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Fanzors are RNA-Guided Nucleases Encoded in Eukaryotic Genomes

Technology / Case number: #24942
Omar Abudayyeh / Jonathan S. Gootenberg / Justin Lim / Kaiyi Jiang
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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A Method for Hierarchical Time Series Reconciliation via Learning the Optimal Projection

Technology / Case number: #26179J
Georgia Perakis / Pin-Yu Chen / Yada Zhu / Asterios Tsiourvas / Wei Sun
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Sensing & Imaging
Impact Areas: Connected World
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Methods, Procedures, and Material Compositions to Formulate Thermally Stable Solid-State Lipid Nanoparticles via Drying at Ambient Conditions

Technology / Case number: #26177
Ana Jaklenec / Robert Langer / Mina Konakovic Lukovic / Jinbi Tian / Khanh Tran / Amy Lee
Technology Areas: Biotechnology / Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Innate Immune Modulating RNA Vaccines

Technology / Case number: #26293H
B.j. Kim / Darrell J Irvine
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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AO mRNA-LNP Stabilization

Technology / Case number: #26266
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Jooli Han / Tina Huang
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Optical Ising Machine and Optical Convolutional Neural Networks

Technology / Case number: #19700
Scott Skirlo / Yichen Shen / Tena Dubcek Varga / Li Jing / Charles Roques-Carmes / Hengameh Bagherianlemraski / Marin Soljacic
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Sensing & Imaging
Impact Areas: Connected World
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Prolonged-Release Hydrogel Formulations of Toll-Like Receptor Agonists for Intratumoral Injection to Increase Immunotherapy Response

Technology / Case number: #23215J
Giovanni Traverso / Robert Langer / Arijit Basu / Avik Som / Jan-Georg Rosenboom / Gabrielle Ndakwah / Eric Wehrenberg-Klee / Umar Mahmood
Technology Areas: Therapeutics
Impact Areas: Healthy Living
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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Jesse C Patterson / Michael Yaffe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Lipid-Polymer Microparticles (mLPM) For Thermostable, Pulsatile mRNA-LNP Vaccines

Technology / Case number: #26154
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Yuting Huang
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Polymeric Core-Shell Particles for Pulsatile Release of HIV Vaccine

Technology / Case number: #26230
Ana Jaklenec / Robert Langer / Maria Kanelli / Behnaz Eshaghi / Amy Lee / Rishi Das / Aki Gurram / Stacey Lin
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Giovanni Traverso / Yunhua Shi / Ameya Kirtane / Grace Junyue Zhong / Daniel Reker / Robert Langer / Hyunjoon Kim / Netra Kamat / James Byrne / Gary Liu
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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