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Programmable Immunostimulation with Structured DNA Nanoparticles

Technology / Case number: #24273H
Mark Bathe / Remi Veneziano / Rebecca Du / Tyson Moyer / Eike-Christian Wamhoff / Benjamin Read / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Compositions for the Conditional Delivery of Macromolecules and Combination Therapeutics

Technology / Case number: #24492H
Chayanon Ngambenjawong / Edward Tan / Qian Zhong / Sangeeta Bhatia
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes

Technology / Case number: #24582H
Ivan Pires / Darrell J Irvine / Paula Hammond
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Targeted Layered Lipid Nanoparticles for in Vivo Extrahepatic Gene Delivery

Technology / Case number: #24751
Namita Nabar / Tamara Dacoba / Paula Hammond
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Modulating Oncogenic Transcriptional Dysregulation with Small Molecule Chimeric Degraders of Cyclin-Dependent Kinase 9

Technology / Case number: #24831
Angela Koehler / Mohammed Toure / Keisuke Motoyama
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Polystyrene Coated Magnetic Beads Serving as Raman Reporter for Simultaneous Target Binding and Identification

Technology, Tangible Property / Case number: #25081
Loza Tadesse / Marissa Morales / Jongwan Lee / Nikiwe Mhlanga
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Tandem Peptide Approaches for Delivery to Gram-Negative Bacteria

Technology / Case number: #19017H
Ester Kwon / Leslie Chan / Sangeeta Bhatia
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Control Replication and Transcription of Self-Replicating RNA in Responses to Small Molecule TMP

Technology / Case number: #22331H
Ron Weiss / Yingzhong Li / Jan Lonzaric / Parisa Yousefpour / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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STING Agonist Delivery by Lipid Nanodiscs for Tumor Immunotherapy

Technology / Case number: #21441HJ
Eric Dane / Masanori Okaniwa / Darrell J Irvine
Technology Areas: Chemicals & Materials / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Multiplexed in Vivo Disease Sensing with Nucleic Acid-Barcoded Reporters enabling CRISPR-Cas-based Detection

Technology / Case number: #21723H
Liang Hao / Renee Zhao / Chayanon Ngambenjawong / Sangeeta Bhatia
Technology Areas: Biotechnology / Chemicals & Materials / Diagnostics
Impact Areas: Healthy Living
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Uses of Amphiphiles in Immune Cell Therapy and Compositions Therefore

Technology / Case number: #21411H
Peter DeMuth / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Solid-State Electrolytes from Hydroboration of Rubber

Technology / Case number: #21696
Jeremiah A. Johnson / Jeffrey Lopez / Teruhiko Saito / Sipei Li / Megan Hill / Yang Shao-Horn
Technology Areas: Chemicals & Materials / Energy & Distribution
Impact Areas: Advanced Materials
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1. Methods for in Vitro Evolution of Constructs Derived from Viruses. 2. Five Mutations Derived from the in Vitro Evolution. 3. Seventeen constructs from the five mutations.

Technology / Case number: #20395H
Ron Weiss / Yingzhong Li / Darrell J Irvine
Technology Areas: Biotechnology / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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PROTAC Derivatives with Functional Handles for Chemical Conjugation/Modification

Technology / Case number: #20788J
Jeremiah A. Johnson / Yivan Jiang / Hung Nguyen / Alexandre Detappe / Irene Ghobrial / Michael Agius / Aiden Wang
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Immunostimulatory Nanoparticle Adjuvants

Technology / Case number: #20798HJ
Murillo Silva / Yu Kato / Shane Crotty / Darrell J Irvine
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Thermally-Drawn Li-Ion Fibre Batteries

Technology / Case number: #20099
Chong Hou / Benjamin Grena / Tural Khudiyev / Jung Tae Lee / Yoel Fink
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
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Ultrafast Single-Step High-Density Conjugation of Quantum Dots and Rods with 2D Lattice Templated Array Alignment using DNA Origami

Technology / Case number: #24671
Mark Bathe / Rob Macfarlane / Chi Chen / Xin Luo
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
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Peptide-Encoded Libraries of Small Molecules for De Novo Drug Discovery

Technology / Case number: #23712
Bradley L. Pentelute / Nathalie Grob / Simon Roessler / Stephen Buchwald
Technology Areas: Biotechnology / Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
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Crosslinked Hydrocarbon Fragments and Methods of Use Thereof

Technology / Case number: #21909
Jeremiah A. Johnson / Wenxu Zhang / Peyton Shieh / Keith Husted
Technology Areas: Chemicals & Materials
Impact Areas: Sustainable Future, Advanced Materials
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Remoldable and Self-Healing Thermoset Materials

Technology / Case number: #22307
Jeremiah A. Johnson / Peyton Shieh / Keith Husted / Christopher Brown / Samantha Kristufek
Technology Areas: Chemicals & Materials
Impact Areas: Advanced Materials
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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