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Plk1 inhibitor and Microtubule Poison Dual Payload Antibody Drug Conjugates for the Treatment of Cancer

Technology / Case number: #26136
Jesse C Patterson / Michael Yaffe
Technology Areas: Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Utilizing a Strategic Blend of Block Copolymers to Control Particle Surface Charge for Enhanced Mucus Transport and Tissue Targeting

Technology / Case number: #25439J
Katharina Ribbeck / Corey Alfred Stevens / Robert Prud'homme / Boris Sevarika / Brian Wilson / Angela Belcher
Technology Areas: Biotechnology / Chemicals & Materials
Impact Areas: Healthy Living
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Lipid-Polymer Microparticles (mLPM) For Thermostable, Pulsatile mRNA-LNP Vaccines

Technology / Case number: #26154
Ana Jaklenec / Robert Langer / Linzixuan Rhoda Zhang / Yuting Huang
Technology Areas: Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Polymeric Core-Shell Particles for Pulsatile Release of HIV Vaccine

Technology / Case number: #26230
Ana Jaklenec / Robert Langer / Maria Kanelli / Behnaz Eshaghi / Amy Lee / Rishi Das / Aki Gurram / Stacey Lin
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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Branched Poly(-amino esters) for the Delivery of Nucleic Acids

Technology / Case number: #20333JQ
Giovanni Traverso / Yunhua Shi / Ameya Kirtane / Grace Junyue Zhong / Daniel Reker / Robert Langer / Hyunjoon Kim / Netra Kamat / James Byrne / Gary Liu
Technology Areas: Biotechnology / Drug Delivery / Therapeutics
Impact Areas: Healthy Living
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Amino Acid, Peptide, Polypeptide-Lipids (APPL) Derivatives and Uses Thereof

Technology / Case number: #14910Q
Kevin Love / Arturo Vegas / Delai Chen / Yi Chen / Yizhou Dong / Yunlong Zhang / Akinleye Alabi / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
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An Ultra-Wide-Band-Gap Semiconductor Optical Switch that is Capable of Fast Turn-Off and Achieves High Current Density with Visible Light at Low Irradiance

Technology / Case number: #26249
Rafael Jaramillo / Jiahao Dong
Technology Areas: Electronics & Photonics / Sensing & Imaging
Impact Areas: Advanced Materials
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Patient-Specific Benchtop Beating Heart Simulator for Recreating Left Atrial Biomechanics and Hemodynamics for LAA Closure and HFpEF Intervention Testing

Technology / Case number: #25761
Ellen Roche / Keegan Mendez / Manisha Singh
Technology Areas: Biomaterials & Bioelectronics / Biotechnology
Impact Areas: Healthy Living
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Colloidal Hydrogel Particles with tunable Chemistry, Geometry, and Flexibility

Technology / Case number: #13461J
Patrick Doyle / Daniel Pregibon / Ramin Haghgooie / Mehmet Toner
Technology Areas: Chemicals & Materials / Computer Science
Impact Areas: Healthy Living
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Velocimetric Sensing and High-Speed Transport Method and Apparatus for Magnetically-Tagged Biological and Chemical Entities Using Magnetic Domain Walls in Lithographically Defined Thin-Film Magnetic

Technology / Case number: #14609
Geoffrey Stephen Beach / Elizabeth Rapoport
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
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Absorbing Films Deposited and Patterned with Soft Lithography

Technology / Case number: #12080
Michael Bradley / Vladimir Bulovic / Jonathan Tischler
Technology Areas: Chemicals & Materials / Electronics & Photonics / Industrial Engineering & Automation
Impact Areas: Advanced Materials
License

M-Blocks: Modular Angular-Momentum Driven Magnetically Connected Robots

Technology / Case number: #16230
Daniela Rus / John Romanishin / Kyle Gilpin
Technology Areas: Industrial Engineering & Automation
Impact Areas: Advanced Materials
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All-Optical Three-Dimensional Compression of Electron Pulses for Ultrafast Electron Imaging

Technology / Case number: #17343
Liang Jie Wong / Nuh Gedik / Timm Rohwer / Byron Freelon / Steven G Johnson
Technology Areas: Chemicals & Materials / Communication Systems / Sensing & Imaging
Impact Areas: Connected World, Advanced Materials
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Fuse Protected Avalanche Photodiode Arrays

Technology / Case number: #16733L
Michael Grzesik
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
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Printed Circuit Board with Rohacell Hybrid Via Process

Technology / Case number: #17133L
Glenn Brigham
Technology Areas: Chemicals & Materials / Electronics & Photonics
Impact Areas: Advanced Materials
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Methods for Microbial Oil Overproduction from Cellulosic Materials

Technology / Case number: #15695
Mitchell Tai / Gregory Stephanopoulos
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Environmental Engineering
Impact Areas: Healthy Living, Sustainable Future
License

Hand Exoskeleton System for Data Collection

Technology / Case number: #26180
Branden Romero / Pulkit Agrawal / Edward Adelson / Haoshu Fang / Arthur Hu
Technology Areas: Biotechnology / Computer Science
Impact Areas: Healthy Living
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Expression Constructs for One-Step Construction of Allogeneic CAR-NK Cells

Technology, Tangible Property / Case number: #26118J
Rizwan Romee / Fuguo Liu / Jianzhu Chen
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Connected World
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Methods for Improving Statistical Power in Genetic Discovery by Incorporating Quality Control Flags

Technology / Case number: #25839P
Manolis Kellis / Yosuke Tanigawa
Technology Areas: Computer Science / Drug Discovery and Research Tools
Impact Areas: Healthy Living
License

Transformer Stand to Sit Robot

Technology / Case number: #25883
Emily Kamienski / Harry Asada
Technology Areas: Biotechnology / Industrial Engineering & Automation
Impact Areas: Healthy Living
License

The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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