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Structure-Guided Chemical Modification of Guide RNA and its Applications

Technology / Case number: #19175V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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sgRNA Chemical Modification for Efficient Gene Editing

Technology / Case number: #17805V
Hao Yin / Robert Langer / Daniel Anderson
Technology Areas: Biotechnology / Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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All-Optical Logic and Quantum-Limited Signal Processing in Large-Scale Optoelectronic Circuits

Technology / Case number: #25208J
Dirk R Englund / Ryan Hamerly / Saumil Bandyopadhyay
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML)
Impact Areas: Uncharted Frontiers, Connected World
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Learning Closed-Loop Control Policies for Manufacturing

Technology / Case number: #23744J
Wojciech Matusik / Piotr Didyk / Michael Foshey / Szymon Rusinkiewicz / Bernd Bickel / Michal Piovarèi
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Sustainable Future
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Microbial Production of Alpha-Substituted 3-Hydroxy Acids from Glucose

Technology / Case number: #25163
Kristala L Jones Prather / K'yal Bannister
Technology Areas: Biotechnology / Drug Discovery and Research Tools
Impact Areas: Healthy Living
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Decoding via Guessing Noise

Technology / Case number: #20169J
Jiange Li / Kenneth Duffy / Muriel Medard
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Computer Science
Impact Areas: Uncharted Frontiers
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Decoding by Guessing Noise II

Technology / Case number: #20215J
Kenneth Duffy / Muriel Medard
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Computer Science
Impact Areas: Connected World, Advanced Materials
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Attention Buffer

Technology / Case number: #18153QJ
Bryan Reimer / Joseph Coughlin / Bruce L Mehler / Joonbum Lee / Linda Angell / Bobbie Seppelt
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Industrial Engineering & Automation
Impact Areas: Uncharted Frontiers
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Ionizable Lipids for Messenger RNA Delivery

Technology, Tangible Property / Case number: #24861
Jacob Witten / Idris Raji / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Synthesis of Ester, Carbonate, and Carbamate-derived Novel Biodegradable Ionizable Lipids from Methyl Ricinoleate or Methyl 12-Hydroxystearate and its Applications

Technology / Case number: #23381Q
Luke Rhym / Bowen Li / Akiva Gordon / rajith manan / Jacob Witten / Daniel Anderson
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living, Advanced Materials
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Attention Maps

Technology / Case number: #18155QJ
Bryan Reimer / Joseph Coughlin / Bruce L Mehler / Joonbum Lee / Andres Munoz Delgado / Linda Angell / Bobbie Seppelt
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Sensing & Imaging
Impact Areas: Healthy Living, Connected World
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A Software System to Synthetically Generate Test Data for Testing Large Scale Software Applications

Technology / Case number: #18981J
Kalyan Veeramachaneni / Neha Patki / Jeffery Wilkinson / Kishore Durg / Sunder Nochilur
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science
Impact Areas: Uncharted Frontiers
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Engineered Synthetic IRES with Improved and Robust Translation in Circular RNA

Technology / Case number: #25300YJ
James Collins / Katherine Ilia / Shiva Razavi / Kehan Zhang / Xiaoyu Chen / Makoto Lalwani / Yu Li / Nayoung Kim
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Single-shot 16-fold Expansion Microscopy (16ExM)

Technology / Case number: #24859MH
Edward Stuart Boyden / Laura L Kiessling / Tay Won Shin / Shiwei Wang / Yixi Liu / Harley Yoder
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Sensing & Imaging
Impact Areas: Healthy Living
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Clockwise Learning Task

Technology / Case number: #25128M
Georgios Papageorgiou / Ann M. Graybiel
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Drug Discovery and Research Tools
Impact Areas: Healthy Living, Uncharted Frontiers
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Reconstituted Lipoprotein Particles to Rescue Lipid Defects in the Alzheimer's Brain

Technology / Case number: #25445P
Li-Huei Tsai / Rebecca Pinals
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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Deep Context Maps

Technology / Case number: #22949
Daniela Rus / Guy Rosman / Sertac Karaman / Igor Gilitschenski / Arjun Gupta
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Computer Science / Sensing & Imaging
Impact Areas: Healthy Living, Connected World
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Scalable Ultra Low Latency Photonic Tensor Processor

Technology / Case number: #23088
Dirk R Englund / Liane Sarah Bel Bernstein / Alexander Sludds
Technology Areas: Artificial Intelligence (AI) and Machine Learning (ML) / Communication Systems / Computer Science
Impact Areas: Healthy Living, Advanced Materials
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Optimized Alum-Anchored HIV Env Immunogens

Technology / Case number: #24972HJ
Kristen Rodrigues / Christopher Cottrell / Jon Steichen / William Schief / Darrell J Irvine
Technology Areas: Drug Delivery / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
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The technologies listed represent a selection of the MIT intellectual property protected by the TLO.

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